Our hit-to-lead efforts is to demonstrate such theranostic contrast for simultaneous magnetic resonance imaging T2 relaxivity and hysteresis-induced thermal activation therapy due to iron oxide core. Once accumulation occurs, ideally the imaging or therapeutic contrast should scale more than linearly with the number of assembled MNS. We envision development, characterization and preclinical validation of magnetic nanostructures (MNS) based "smart" nanoplatforms that will selectively accumulate and aggregate within tumors in vivo. The prevalence and gravity of the disorder, its refractoriness to current approaches, and the toxicity and disabilities caused by current therapies suggest that fundamentally new approaches must be developed. Research Scientist Materials Science and Engineering Northwestern University Room: B560, Silverman Hall Chemistry of Life Processes Institute, 2170 Campus Drive, Evanston IL, 60208-3113 Phone: (847) 467-2651 Facsimile: (847) 491-7280 Email: Research ProjectsÄespite substantial progress in the treatment of cancer, it remains the second leading cause of death in the United States and is expected to become the leading cause of death within the next decade.
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